{"id":21840,"date":"2025-06-04T07:47:52","date_gmt":"2025-06-04T07:47:52","guid":{"rendered":"https:\/\/www.nf1pn.eu\/diagnosi-e-gestione\/"},"modified":"2026-03-12T13:40:34","modified_gmt":"2026-03-12T13:40:34","slug":"diagnosi-e-gestione","status":"publish","type":"page","link":"https:\/\/www.nf1pn.eu\/it\/diagnosi-e-gestione\/","title":{"rendered":"Diagnosi e gestione"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21840\" class=\"elementor elementor-21840 elementor-21698\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3cd4fc11 e-flex e-con-boxed e-con e-parent\" data-id=\"3cd4fc11\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-338db3c9 e-con-full e-flex e-con e-child\" data-id=\"338db3c9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61472a6b elementor-widget elementor-widget-spacer\" data-id=\"61472a6b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fc43022 the7-e-sticky-row-yes e-con-full e-flex e-con e-child\" data-id=\"1fc43022\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t<div class=\"elementor-element elementor-element-32fbd66d e-con-full e-flex e-con e-child\" data-id=\"32fbd66d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3a44d26c elementor-widget elementor-widget-text-editor\" data-id=\"3a44d26c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#diagnosis-section\">Diagnosi<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a28bdd1 e-con-full e-flex e-con e-child\" data-id=\"6a28bdd1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3519c2d1 elementor-widget elementor-widget-text-editor\" data-id=\"3519c2d1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#management-section\">Gestione<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b6b8b1a e-con-full e-flex e-con e-child\" data-id=\"3b6b8b1a\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5d7a926e e-flex e-con-boxed e-con e-child\" data-id=\"5d7a926e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32faf2a5 elementor-widget elementor-widget-heading\" data-id=\"32faf2a5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Diagnosi e gestione della NF1-PN<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-166ec6f8 e-con-full section e-flex e-con e-child\" data-id=\"166ec6f8\" data-element_type=\"container\" id=\"diagnosis-section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-2b8c8da6 e-flex e-con-boxed e-con e-child\" data-id=\"2b8c8da6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-427c1988 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"427c1988\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Diagnosi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31fab517 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"31fab517\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-31fab517\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 6.10395C67.7217 -0.910952 56.3558 -0.910952 49.3409 6.10395C46.6339 8.81093 44.9986 12.1634 44.3831 15.6623C44.3659 15.7441 44.3401 15.8 44.3229 15.8775C42.4594 25.6295 44.6069 32.6315 32.3029 44.9398C19.9945 57.2439 18.4151 53.9645 8.28867 57.3472L8.3231 57.3859C6.57583 57.954 4.91894 58.8835 3.52887 60.2693C-1.17499 64.9775 -1.17499 72.6035 3.52887 77.3073C8.23703 82.0155 15.863 82.0155 20.5669 77.3073C21.957 75.9173 22.8866 74.2604 23.4546 72.5131L23.4934 72.5475C26.876 62.4168 23.5966 60.8417 35.9007 48.5333C48.2048 36.225 55.211 38.3725 64.963 36.5133C65.0448 36.5004 65.0965 36.4703 65.1739 36.4531C68.6771 35.8377 72.0339 34.198 74.7366 31.491C81.7515 24.4804 81.7515 13.1102 74.7366 6.09534\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2226_241)\"><path d=\"M47.0557 45.4884C46.3574 47.8483 45.0716 50.0728 43.1982 51.9336C37.2205 57.8714 27.53 57.8714 21.5522 51.9336C15.5744 45.9959 15.5744 36.3703 21.5522 30.4325C23.4596 28.5378 25.7417 27.2522 28.1686 26.5586\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M45.114 49.9209L56.6353 61.365C57.7508 62.4731 57.7508 64.2832 56.6353 65.3912L56.4564 65.5688C55.3409 66.6769 53.5186 66.6769 52.4031 65.5688L40.8818 54.1247\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M27.5469 43.6792L37.842 25.5191L47.7964 36.1936L57.3507 19.0654\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M41.4268 25.5193C41.4268 27.4816 39.8259 29.0718 37.8504 29.0718C35.8748 29.0718 34.2739 27.4816 34.2739 25.5193C34.2739 23.557 35.8748 21.9668 37.8504 21.9668C39.8259 21.9668 41.4268 23.557 41.4268 25.5193Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M31.1231 43.6795C31.1231 45.6418 29.5222 47.232 27.5467 47.232C25.5711 47.232 23.9702 45.6418 23.9702 43.6795C23.9702 41.7171 25.5711 40.127 27.5467 40.127C29.5222 40.127 31.1231 41.7171 31.1231 43.6795Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M51.3809 36.1931C51.3809 38.1555 49.78 39.7456 47.8045 39.7456C45.8289 39.7456 44.228 38.1555 44.228 36.1931C44.228 34.2308 45.8289 32.6406 47.8045 32.6406C49.78 32.6406 51.3809 34.2308 51.3809 36.1931Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M60.9356 19.0652C60.9356 21.0275 59.3347 22.6177 57.3592 22.6177C55.3836 22.6177 53.7827 21.0275 53.7827 19.0652C53.7827 17.1029 55.3836 15.5127 57.3592 15.5127C59.3347 15.5127 60.9356 17.1029 60.9356 19.0652Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2226_241\"><rect width=\"46\" height=\"53\" fill=\"white\" transform=\"translate(16 14.4551)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>I neurofibromi plessiformi (PN) correlati alla neurofibromatosi di tipo 1 (NF1) crescono <b>rapidamente nella prima infanzia<\/b> e richiedono <b>una valutazione, una diagnosi e un intervento<\/b> tempestivi per una gestione efficace.<sup>1<\/sup><br\/>\nUna <b>raccomandazione del consenso internazionale<\/b> descrive in dettaglio i criteri diagnostici per <b>stabilire una diagnosi di NF1.<\/b> I criteri diagnostici sono soddisfatti in un soggetto se sono presenti due o pi\u00f9* dei seguenti elementi:<sup>2, 3<\/sup><\/p><ul>\n<li>Sei o pi\u00f9 <b>macule color caffellatte<\/b><\/li>\n<li><b>Lentigginosi<\/b> nella regione ascellare o inguinale<\/li>\n<li>Due o pi\u00f9 neurofibromi di qualsiasi tipo o un <b>neurofibroma plessiforme<\/b><\/li>\n<li>Glioma delle vie ottiche<\/li>\n<li>Due o pi\u00f9 noduli di Lisch nell\u2019iride<\/li>\n<li>Una lesione ossea caratteristica<\/li>\n<li>Una variante patogenetica in eterozigosi del gene NF1<\/li><\/ul>\n<small>*Uno o pi\u00f9 se il soggetto ha un genitore a cui \u00e8 stata diagnosticata la NF1<\/small>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2af5cc13 section e-con-full e-flex e-con e-child\" data-id=\"2af5cc13\" data-element_type=\"container\" id=\"management-section\">\n\t\t<div class=\"elementor-element elementor-element-562bd113 e-flex e-con-boxed e-con e-child\" data-id=\"562bd113\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-72f9acf4 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"72f9acf4\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Gestione della NF1-PN<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b4fbf57 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"7b4fbf57\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-7b4fbf57\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 5.64887C67.7217 -1.36603 56.3558 -1.36603 49.3409 5.64887C46.6339 8.35585 44.9986 11.7084 44.3831 15.2072C44.3659 15.289 44.3401 15.3449 44.3229 15.4224C42.4594 25.1744 44.6069 32.1764 32.3029 44.4847C19.9945 56.7888 18.4151 53.5094 8.28867 56.8921L8.3231 56.9308C6.57583 57.4989 4.91894 58.4285 3.52887 59.8142C-1.17499 64.5224 -1.17499 72.1484 3.52887 76.8523C8.23703 81.5604 15.863 81.5604 20.5669 76.8523C21.957 75.4622 22.8866 73.8053 23.4546 72.058L23.4934 72.0925C26.876 61.9617 23.5966 60.3866 35.9007 48.0783C48.2048 35.7699 55.211 37.9174 64.963 36.0583C65.0448 36.0453 65.0965 36.0152 65.1739 35.998C68.6771 35.3826 72.0339 33.7429 74.7366 31.0359C81.7515 24.0253 81.7515 12.6552 74.7366 5.64026\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2227_662)\"><path d=\"M51.9152 48.7373C49.0797 52.17 44.7927 54.3612 39.9968 54.3612C31.4634 54.3612 24.5512 47.4483 24.5512 38.914H28.6822L22.2652 27.7949L15.8481 38.914H19.8503C19.8503 50.0466 28.8722 59.0694 40.0036 59.0694\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M28.0781 29.0831C30.9136 25.6503 35.2006 23.4591 39.9965 23.4591C48.5299 23.4591 55.4421 30.372 55.4421 38.9064H51.3111L57.7281 50.0254L64.1451 38.9064H60.143C60.143 27.7738 51.1211 18.751 39.9897 18.751\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 32.7129H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 32.7198L34.9839 34.3615L38.2806 31.0645\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 38.9131H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 38.92L34.9839 40.5617L38.2806 37.2646\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 45.1074H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 45.1143L34.9839 46.756L38.2806 43.459\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2227_662\"><rect width=\"50\" height=\"42\" fill=\"white\" transform=\"translate(15 17.9102)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Le linee guida europee ERN GENTURIS per la gestione della NF1 raccomandano un <b>approccio multidisciplinare (MDT),<\/b> che coinvolge specialisti con esperienza nel trattamento della <b>NF1-PN<\/b>.<sup>3, 4<\/sup><br\/>\nLe <b>opzioni di trattamento<\/b> per i pazienti con NF1-PN includono monitoraggio attivo, terapia sintomatica, intervento chirurgico e terapia farmacologica mirata.<sup>4, 5<\/sup><br\/>\nLe <b>linee guida per la gestione della NF1-PN<\/b> <b>suggeriscono la terapia medica <\/b>come opzione di trattamento attivo per i PN sintomatici e i PN sintomatici inoperabili.<sup>4, 5<\/sup><\/p><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c6cc0b0 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"3c6cc0b0\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Monitoraggio dei pazienti con NF1-PN<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1187c01a no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"1187c01a\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-1187c01a\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 6.21821C67.7217 -0.796694 56.3558 -0.796694 49.3409 6.21821C46.6339 8.92518 44.9986 12.2777 44.3831 15.7765C44.3659 15.8583 44.3401 15.9143 44.3229 15.9917C42.4594 25.7437 44.6069 32.7457 32.3029 45.0541C19.9945 57.3581 18.4151 54.0788 8.28867 57.4614L8.3231 57.5001C6.57583 58.0682 4.91894 58.9978 3.52887 60.3836C-1.17499 65.0917 -1.17499 72.7178 3.52887 77.4216C8.23703 82.1298 15.863 82.1298 20.5669 77.4216C21.957 76.0315 22.8866 74.3746 23.4546 72.6274L23.4934 72.6618C26.876 62.5311 23.5966 60.9559 35.9007 48.6476C48.2048 36.3392 55.211 38.4867 64.963 36.6276C65.0448 36.6147 65.0965 36.5845 65.1739 36.5673C68.6771 35.9519 72.0339 34.3122 74.7366 31.6053C81.7515 24.5947 81.7515 13.2245 74.7366 6.2096\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2227_878)\"><path d=\"M15.6924 49.2838L23.7483 37.1743L28.317 43.366L39.6486 24.9942L45.2517 32.2584L55.3451 18.458\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M14.9795 60.501H64.0204\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.6377 54.7793H29.1717\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.6377 49.8867H29.1717\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 54.7793H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 49.8867H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 45.002H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M49.9932 54.7793H58.5271\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M49.9932 49.8867H53.5039\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M52.2027 29.4247C52.2027 35.1938 47.5243 39.867 41.7488 39.867C35.9733 39.867 31.2949 35.1938 31.2949 29.4247C31.2949 23.6556 35.9733 18.9824 41.7488 18.9824C47.5243 18.9824 52.2027 23.6556 52.2027 29.4247Z\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M50.6433 35.1074L61.7398 46.1916C62.5548 47.0057 62.5548 48.3364 61.7398 49.1505L61.6065 49.2835C60.7916 50.0976 59.4593 50.0976 58.6443 49.2835L47.5479 38.1994\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2227_878\"><rect width=\"51\" height=\"44\" fill=\"white\" transform=\"translate(14 17.4795)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>La <b>valutazione clinica<\/b> mediante osservazione, palpazione ed esame neurologico deve essere eseguita regolarmente da <b>medici con esperienza nella NF1-PN<\/b>.<sup>3, 4<\/sup><br\/>\nLa diagnostica per immagini mediante <b>RM dell\u2019intero corpo<\/b> deve essere eseguita almeno al momento della transizione <b>dall\u2019adolescenza all\u2019et\u00e0 adulta<\/b>.<sup>3, 4<\/sup><br\/>\nLa valutazione clinica deve essere <b>avviata alla diagnosi o alla nascita<\/b> e ripetuta a ogni visita clinica, almeno:<sup>4<\/sup><\/p>\n<ul><li>Ogni anno nei bambini fino a 10 anni<\/li>\n<li>Una volta ogni due anni nei bambini di et\u00e0 superiore a 10 anni<\/li><li>Una volta ogni tre anni negli adulti<\/li>\n<li>Durante la transizione dall\u2019adolescenza all\u2019et\u00e0 adulta, potrebbe essere giustificata una valutazione clinica pi\u00f9 frequente.<\/li><\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14dd9c29 e-con-full e-flex e-con e-child\" data-id=\"14dd9c29\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-3b000002 e-flex e-con-boxed e-con e-child\" data-id=\"3b000002\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7feebbb e-con-full e-flex e-con e-child\" data-id=\"7feebbb\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27d0bde0 elementor-widget elementor-widget-the7-accordion\" data-id=\"27d0bde0\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-6671\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-6671\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">Riferimenti<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-6671\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-6671\"><ol>\n<li>Gross AM et al. Association of plexiform neurofibroma volume changes and development of clinical morbidities in neurofibromatosis 1. <i>Neuro Oncol <\/i>2018;20(12):1643\u20131651.<\/li>\n<li>Legius E et al. Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: An international consensus recommendation. <i>Genet Med<\/i>. 2021;23(8):1506-1513.<\/li>\n<li>Farschtschi S, Vaassen P, Kluwe L, Hartung T, Salamon J, Rosenbaum T. Age adapted diagnostic evaluation and treatment of patients with neurofibromatosis type 1 in Germany. <i>Dtsch Arztebl Int<\/i> 2025; 112 (3)<\/li>\n<li>Carton C et al. ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1.<i> eClinicalMedicine<\/i>. 2023;56:101818.<\/li>\n<li>Fisher MJ, Blakeley JO, Weiss BD, et al. Management of neurofibromatosis type 1-associated plexiform neurofibromas.<i> Neuro Oncol<\/i>. 2022;24(11):1827-1844.<\/li>\n<\/ol>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Diagnosi Gestione Diagnosi e gestione della NF1-PN Diagnosi I neurofibromi plessiformi (PN) correlati alla neurofibromatosi di tipo 1 (NF1) crescono rapidamente nella prima infanzia e richiedono una valutazione, una diagnosi e un intervento tempestivi per una gestione efficace.1 Una raccomandazione del consenso internazionale descrive in dettaglio i criteri diagnostici per stabilire una diagnosi di NF1.&hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-21840","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NF1-PN: Risorse e video degli esperti | SpringWorks Therapeutics<\/title>\n<meta name=\"description\" content=\"Accesso alle pubblicazioni sul trattamento della NF1-PN, ai recapiti del gruppo di supporto da condividere con i pazienti e ai video degli esperti.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.nf1pn.eu\/it\/diagnosi-e-gestione\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" 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