{"id":21896,"date":"2024-08-02T11:02:59","date_gmt":"2024-08-02T11:02:59","guid":{"rendered":"https:\/\/www.nf1pn.eu\/carga-y-necesidades-insatisfechas\/"},"modified":"2026-03-12T11:32:05","modified_gmt":"2026-03-12T11:32:05","slug":"carga-y-necesidades-insatisfechas","status":"publish","type":"page","link":"https:\/\/www.nf1pn.eu\/es\/carga-y-necesidades-insatisfechas\/","title":{"rendered":"Carga y necesidades insatisfechas"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21896\" class=\"elementor elementor-21896 elementor-20178\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b240aa3 e-con-full e-flex e-con e-parent\" data-id=\"2b240aa3\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-759415ae e-flex e-con-boxed e-con e-child\" data-id=\"759415ae\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-66efe0dd elementor-widget elementor-widget-spacer\" data-id=\"66efe0dd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f734eb5 the7-e-sticky-row-yes e-flex e-con-boxed e-con e-child\" data-id=\"7f734eb5\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e847515 e-con-full e-flex e-con e-child\" data-id=\"2e847515\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f65c64c elementor-widget elementor-widget-text-editor\" data-id=\"7f65c64c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#disease-burden\">Carga de la enfermedad NF1-NP<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ceb674a e-con-full e-flex e-con e-child\" data-id=\"1ceb674a\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d790e2e elementor-widget elementor-widget-text-editor\" data-id=\"6d790e2e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#unmet-needs\">NF1-NP: un complejo desaf\u00edo cl\u00ednico<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-589832e6 e-con-full e-flex e-con e-child\" data-id=\"589832e6\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-c161125 e-flex e-con-boxed e-con e-child\" data-id=\"c161125\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a1a495b elementor-widget elementor-widget-heading\" data-id=\"2a1a495b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Carga de la enfermedad y necesidades insatisfechas<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2ae28505 e-con-full section e-flex e-con e-child\" data-id=\"2ae28505\" data-element_type=\"container\" id=\"disease-burden\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1146bb06 e-flex e-con-boxed e-con e-child\" data-id=\"1146bb06\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e715ad5 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"7e715ad5\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Carga de la enfermedad NF1-NP<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-894f0bf elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"894f0bf\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Posible impacto en la vida cotidiana<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f196caf elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"4f196caf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLos pacientes afectados por la NF1-NP y sus cuidadores suelen enfrentarse a una reducci\u00f3n de la calidad de vida que va m\u00e1s all\u00e1 de los s\u00edntomas f\u00edsicos de la enfermedad.\n\nEsta compleja afecci\u00f3n puede provocar una amplia gama de limitaciones f\u00edsicas, psicol\u00f3gicas y cognitivas que pueden afectar al funcionamiento diario y al bienestar <span style=\"white-space: nowrap;\">general.<sup>1\u20133<\/sup><\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17183449 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"17183449\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-17183449\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"S\u00edntomas f\u00edsicos\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><mask id=\"mask0_2098_3338\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"80\" height=\"81\"><path 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stroke-width=\"1.51398\" stroke-miterlimit=\"10\"><\/path><path d=\"M23.424 32.6149C25.3767 32.6149 27.2133 29.7418 27.2133 27.5139C27.2133 25.4235 25.5143 23.7246 23.424 23.7246C21.3337 23.7246 19.6348 25.4278 19.6348 27.5139C19.6348 29.7418 21.4713 32.6149 23.424 32.6149Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51398\" stroke-miterlimit=\"10\"><\/path><path d=\"M56.8517 32.2194C58.8044 32.2194 60.641 29.3463 60.641 27.1183C60.641 25.028 58.9421 23.3291 56.8517 23.3291C54.7614 23.3291 53.0625 25.0323 53.0625 27.1183C53.0625 29.3463 54.8991 32.2194 56.8517 32.2194Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51398\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"S\u00edntomas f\u00edsicos\">\t\t\t\t\t\t\t\t\t\t\t\tS\u00edntomas 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53.7017L43.9091 55.325C42.2096 55.609 41.2336 54.8853 40.7967 53.2621C40.3395 51.5442 41.1994 50.1103 42.9399 49.7045L50.0996 48.3315\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><\/g><defs><clipPath id=\"clip0_2098_2962\"><rect width=\"35\" height=\"54\" fill=\"white\" transform=\"translate(22 14)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Impacto psicol\u00f3gico\">\t\t\t\t\t\t\t\t\t\t\t\tImpacto psicol\u00f3gico\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><ul><li>Depresi\u00f3n<\/li>\n<li>Ansiedad<\/li>\n<li>Aislamiento<\/li>\n<li>Estigma<\/li>\n<li>Verg\u00fcenza<\/li>\n<li>Miedo al c\u00e1ncer<\/li>\n<li>Deterioro de la salud sexual<\/li><\/ul><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"D\u00e9ficits cognitivos\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"81\" height=\"81\" viewBox=\"0 0 81 81\" fill=\"none\"><mask id=\"mask0_2098_3394\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"81\" height=\"81\"><path d=\"M80.6665 0.0898438H0.666504V80.0898H80.6665V0.0898438Z\" fill=\"white\"><\/path><\/mask><g mask=\"url(#mask0_2098_3394)\"><mask id=\"mask1_2098_3394\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"81\" height=\"81\"><path d=\"M80.6192 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52.215 57.5434 54.4307 56.913C59.6625 55.4245 63.1251 50.171 62.9903 45.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M46.9941 17.9262L50.4684 15.8369L54.2322 18.2372L58.8149 15.8369L59.9895 20.8927L64.9941 21.8975V25.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M25.0068 56.8369L23.9941 59.0507L29.3713 58.6044L32.9381 63.8369L35.9941 59.2344\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M22.9941 21.6016L20.3704 19.8369L19.1988 25.3392L12.9941 27.131L14.57 31.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M53.9941 60.8369L56.4536 61.8369L57.9941 60.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"D\u00e9ficits cognitivos\">\t\t\t\t\t\t\t\t\t\t\t\tD\u00e9ficits cognitivos\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><ul><li>Incapacidad para centrarse<\/li>\n<li>Deterioro de la memoria<\/li>\n<li>Deterioro de la funci\u00f3n visual y motora<\/li>\n<li>Dificultades de aprendizaje<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4a2c6cf6 e-flex e-con-boxed e-con e-child\" data-id=\"4a2c6cf6\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-36e1d0b7 e-flex e-con-boxed e-con e-child\" data-id=\"36e1d0b7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7cb0f92a e-con-full e-flex e-con e-child\" data-id=\"7cb0f92a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4111b324 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"4111b324\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Dolor y desfiguraci\u00f3n: Preocupaciones clave en todas las edades<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76e656a8 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"76e656a8\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"the7-heading-title elementor-size-default\">Entre todos los grupos de edad, dos de las preocupaciones notificadas con m\u00e1s frecuencia entre los pacientes con NF1-NP son el posible dolor y los posibles cambios en el aspecto f\u00edsico.<sup>3<\/sup><br\/>\u2028En ni\u00f1os y adolescentes, se ha descubierto que el dolor afecta su calidad de vida, incluso cuando se utilizan analg\u00e9sicos.<sup>4<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-38072511 section e-flex e-con-boxed e-con e-child\" data-id=\"38072511\" data-element_type=\"container\" id=\"unmet-needs\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-22042c e-con-full e-flex e-con e-child\" data-id=\"22042c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-90ad8b4 e-con-full e-flex e-con e-child\" data-id=\"90ad8b4\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5bd9c565 e-con-full e-flex e-con e-child\" data-id=\"5bd9c565\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-712f2511 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"712f2511\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">NF1-NP: un complejo desaf\u00edo 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stroke-linejoin=\"round\"><\/path><path d=\"M35.1429 31.3258C32.6253 31.3258 30.5811 29.2773 30.5811 26.764C30.5811 24.2507 32.6296 22.2021 35.1429 22.2021C37.6562 22.2021 39.7047 24.2507 39.7047 26.764C39.7047 29.2773 37.6562 31.3258 35.1429 31.3258Z\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M35.1387 54.3457V74.4694\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M29.3801 55.0519L28.2568 40.3809\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M40.9102 55.0519L42.0291 40.3809\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2104_4056\"><rect width=\"80\" height=\"80\" fill=\"white\" transform=\"translate(0 0.0898438)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Crecimiento y distribuci\u00f3n tumoral\">\t\t\t\t\t\t\t\t\t\t\t\tCrecimiento y distribuci\u00f3n tumoral\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\">Los neurofibromas plexiformes (NP) son tumores complejos que pueden desarrollarse en cualquier parte del cuerpo fuera del sistema nervioso central (SNC). Las zonas m\u00e1s comunes donde aparecen son la cabeza y el cuello, seguidas de las extremidades y el tronco.<sup>5<\/sup><br\/>\nEl comportamiento de crecimiento de los NP es impredecible, con periodos de r\u00e1pida expansi\u00f3n que se alternan con fases de relativa inactividad.<sup>6<\/sup>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6496532e e-con-full e-flex e-con e-child\" data-id=\"6496532e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1e4c1ebe elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"1e4c1ebe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>La cirug\u00eda para tratar la NF1-NP no siempre es factible, y los resultados pueden ser variables.<sup>7<\/sup><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fed04e1 no-link icon-box-grid-title-evidence content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"5fed04e1\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-5fed04e1\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Tratamiento quir\u00fargico: Limitaciones y resultados\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"84\" height=\"86\" viewBox=\"0 0 84 86\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7356 5.35102C67.7207 -1.66388 56.3548 -1.66388 49.3399 5.35102C46.633 8.058 44.9976 11.4105 44.3822 14.9094C44.3649 14.9911 44.3391 15.0471 44.3219 15.1245C42.4584 24.8765 44.6059 31.8785 32.3019 44.1869C19.9935 56.4909 18.4141 53.2116 8.2877 56.5942L8.32213 56.633C6.57486 57.201 4.91796 58.1306 3.52789 59.5164C-1.17596 64.2245 -1.17596 71.8506 3.52789 76.5544C8.23605 81.2626 15.8621 81.2626 20.5659 76.5544C21.956 75.1643 22.8856 73.5075 23.4537 71.7602L23.4924 71.7946C26.875 61.6639 23.5957 60.0888 35.8997 47.7804C48.2038 35.4721 55.2101 37.6196 64.9621 35.7604C65.0438 35.7475 65.0955 35.7174 65.173 35.7001C68.6761 35.0847 72.0329 33.445 74.7356 30.7381C81.7505 23.7275 81.7505 12.3573 74.7356 5.34241\" fill=\"#05C0DA\"><\/path><path d=\"M63.6044 24.1366L55.957 16.4893L43.2429 29.2034L50.8902 36.8508L63.6044 24.1366Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M49.1521 35.1155L44.98 30.9434L40.8079 35.1155L44.98 39.2876L49.1521 35.1155Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M42.8931 37.1982L11.1797 68.9116\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.9812 25.4659L44.3302 22.8149C42.5097 20.9945 42.5097 18.0422 44.3302 16.2218C46.1506 14.4013 49.1029 14.4013 50.9276 16.2218L53.5786 18.8728\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M61.222 26.5166L63.873 29.1676C65.6934 30.9881 65.6934 33.9403 63.873 35.7651C62.0526 37.5855 59.1003 37.5855 57.2755 35.7651L54.6245 33.1141\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M67.0876 17.1731L62.9155 13.001L57.6935 18.223L61.8657 22.3951L67.0876 17.1731Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M71.4001 21.4851L58.6055 8.69043\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Tratamiento quir\u00fargico: Limitaciones y resultados\">\t\t\t\t\t\t\t\t\t\t\t\tTratamiento quir\u00fargico: Limitaciones y resultados\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Hist\u00f3ricamente, <b>la opci\u00f3n de tratamiento principal para los NP ha sido la resecci\u00f3n quir\u00fargica<\/b>; sin embargo, los tumores irresecables, las resecciones incompletas y la recidiva tumoral pueden limitar la utilidad de las intervenciones quir\u00fargicas.<sup>8<\/sup><br\/>\n<b>La cirug\u00eda de la NF1-NP<\/b> suele verse <b>limitada<\/b> por la naturaleza infiltrante de los tumores, su ubicaci\u00f3n anat\u00f3mica y su proximidad a nervios y vasos sangu\u00edneos.<sup>2<\/sup><br\/>\n<b>Incluso cuando la cirug\u00eda es factible:<\/b><\/p>\n<ul><li>En muchos casos no es posible extirpar completamente un neurofibroma plexiforme (NP).<sup>9<\/sup><\/li>\n<li>Aproximadamente el 50\u00a0% de los pacientes tienen tumores que no se pueden extirpar por completo.<sup>10<\/sup><\/li>\n<li>Incluso tras resecciones completas confirmadas, el 20\u00a0% de los tumores pueden volver a crecer.<sup>10<\/sup><\/li><\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"La necesidad de m\u00e1s opciones terap\u00e9uticas\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"84\" height=\"86\" viewBox=\"0 0 84 86\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7356 5.35102C67.7207 -1.66388 56.3548 -1.66388 49.3399 5.35102C46.633 8.058 44.9976 11.4105 44.3822 14.9094C44.3649 14.9911 44.3391 15.0471 44.3219 15.1245C42.4584 24.8765 44.6059 31.8785 32.3019 44.1869C19.9935 56.4909 18.4141 53.2116 8.2877 56.5942L8.32213 56.633C6.57486 57.201 4.91796 58.1306 3.52789 59.5164C-1.17596 64.2245 -1.17596 71.8506 3.52789 76.5544C8.23605 81.2626 15.8621 81.2626 20.5659 76.5544C21.956 75.1643 22.8856 73.5075 23.4537 71.7602L23.4924 71.7946C26.875 61.6639 23.5957 60.0888 35.8997 47.7804C48.2038 35.4721 55.2101 37.6196 64.9621 35.7604C65.0438 35.7475 65.0955 35.7174 65.173 35.7001C68.6761 35.0847 72.0329 33.445 74.7356 30.7381C81.7505 23.7275 81.7505 12.3573 74.7356 5.34241\" fill=\"#05C0DA\"><\/path><path d=\"M45.1434 59.79C45.1587 59.9457 45.1682 60.1051 45.1682 60.2645C45.1682 62.802 43.0936 64.8593 40.5347 64.8593H40.3166C37.7577 64.8593 35.6812 62.802 35.6812 60.2645C35.6812 60.1051 35.6888 59.9457 35.7041 59.79\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M55.2505 51.0176L58.1998 53.7486\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.5549 19.8793L34.5635 16\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M27.0209 24.3986L24.3262 21.4189\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M21.5665 32.4202L17.7617 31.0859\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.9407 42.3428L17 43.2101\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M25.6011 51.0176L22.6499 53.7486\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M59.9111 42.3428L63.8518 43.2101\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M59.2832 32.4202L63.0899 31.0859\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M53.8286 24.3986L56.5234 21.4189\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M45.2949 19.8793L46.2863 16\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.8199 60.2648C45.9606 60.2648 48.6017 57.7937 48.6323 54.6793C48.6323 54.6527 48.6323 54.4591 48.6323 54.4591C48.6323 51.9197 49.639 49.4639 51.4706 47.5166C53.9816 44.8501 55.4055 41.3466 55.1319 37.5432C54.6285 30.557 48.2974 24.3965 40.4256 24.3965C32.5539 24.3965 26.2209 30.5589 25.7175 37.5451C25.4438 41.3485 26.8677 44.852 29.3787 47.5185C31.2122 49.4639 32.217 51.9216 32.217 54.461C32.217 54.461 32.217 54.6546 32.217 54.6812C32.2476 57.7956 34.8888 60.2667 38.0295 60.2667H42.8199V60.2648Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M41.8114 55.7913L41.8229 55.7173C42.1846 53.3885 42.5463 52.4681 42.908 50.1394L43.5377 46.0836C43.7597 44.6563 43.8401 41.9784 45.9607 42.1701C47.4382 42.3049 48.1023 44.1401 47.0573 45.1764C45.6142 46.6074 43.3023 46.4005 43.3023 46.4005H37.5511C37.5511 46.4005 35.2391 46.6074 33.7961 45.1764C32.7511 44.1401 33.4152 42.303 34.8927 42.1701C37.0133 41.9765 37.0937 44.6563 37.3157 46.0836L37.9453 50.1394C38.3071 52.4681 38.6688 53.3885 39.0305 55.7173L39.042 55.7913\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"La necesidad de m\u00e1s opciones terap\u00e9uticas\">\t\t\t\t\t\t\t\t\t\t\t\tLa necesidad de m\u00e1s opciones terap\u00e9uticas\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\">Actualmente hay dos tratamientos aprobados en Europa para los pacientes con NF1-NP.<sup>11,12<\/sup> La disponibilidad de opciones terap\u00e9uticas adicionales ser\u00e1 beneficiosa para los pacientes.<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-38ea6d97 e-con-full e-flex e-con e-child\" data-id=\"38ea6d97\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34556022 content-align-left the7-hover-visibility-disabled transform-overlay-yes exceeding-frame-yes elementor-widget elementor-widget-the7-image-widget\" data-id=\"34556022\" data-element_type=\"widget\" data-settings=\"{&quot;hover_visibility&quot;:&quot;disabled&quot;}\" data-widget_type=\"the7-image-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-image-container\"><div class=\"the7-image-wrapper the7-elementor-widget the7-transform-container\"><div class=\"post-thumbnail-rollover layzr-bg img-css-resize-wrapper\"><img decoding=\"async\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039;%20viewBox%3D&#039;0%200%201%201&#039;%2F%3E\" class=\"attachment-full size-full preload-me aspect the7-svg-image lazy lazy-load\" alt=\"\" data-src=\"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2025\/07\/Asset-1-1.svg\" loading=\"eager\" \/><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e7e0681 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"2e7e0681\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Sitios frecuentes de los NP<sup>5<\/sup><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5bb85d8c e-con-full e-flex e-con e-child\" data-id=\"5bb85d8c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1307d719 e-flex e-con-boxed e-con e-child\" data-id=\"1307d719\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-37ac0815 e-con-full e-flex e-con e-child\" data-id=\"37ac0815\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f0b0ed7 elementor-widget elementor-widget-the7-accordion\" data-id=\"f0b0ed7\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2521\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2521\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">Referencias<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2521\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2521\"><ol>\n \t<li>Copley-Merriman C, Yang X, Juniper M, et al. Natural History and Disease Burden of Neurofibromatosis Type 1 with Plexiform Neurofibromas: A Systematic Literature Review. <i>Adolesc Health Med Ther<\/i>. 2021;12:55\u201366. doi: 10.2147\/AHMT.S303456.<\/li>\n \t<li>Fisher MJ, Blakeley JO, Weiss BD, et al. Management of neurofibromatosis type 1-associated plexiform neurofibromas. <i>Neuro Oncol<\/i>. 2022;24(11):1827\u20131844. doi: 10.1093\/neuonc\/noac146.<\/li>\n \t<li>Lai J-S, Jensen SE, Patel ZS, Listernick R, Charrow J. Using a qualitative approach to conceptualize concerns of patients with neurofibromatosis type 1 associated plexiform neurofibromas (pNF) across the lifespan. <i>Am J Med Genet A<\/i>. 2017;173(1):79\u201387. doi: 10.1002\/ajmg.a.37987.<\/li>\n \t<li>Wolters PL, Burns KM, Martin S, et al. Pain interference in youth with neurofibromatosis type 1 and plexiform neurofibromas and relation to disease severity, social-emotional functioning, and quality of life. <i>Am J Med Genet A<\/i>. 2015;167A(9):2103\u20132113. doi: 10.1002\/ajmg.a.37123.<\/li>\n \t<li>Prada CE, Rangwala FA, Martin LJ, et al. Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1. <i>J Pediatr<\/i>. 2012;160(3):461\u2013467. doi: 10.1016\/j.jpeds.2011.08.051.<\/li>\n \t<li>Mrugala M et al. Disease burden and unmet needs in adults with neurofibromatosis type 1 and plexiform neurofibromas: A systematic literature review. Neurooncol Adv. 2026;vdaf269. doi: 10.1093\/noajnl\/vdaf269.<\/li>\n \t<li>Nguyen R, Dombi E, Widemann BC, et al. Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. <i>Orphanet J Rare Dis<\/i>. 2012:7:75. doi: 10.1186\/1750-1172-7-75.<\/li>\n \t<li>Ejerskov C, Farholt S, Nielsen FSK, et al. Clinical characteristics and management of children and adults with neurofibromatosis type 1 and plexiform neurofibromas in Denmark: a nationwide study. <i>Oncol Ther<\/i>. 2023;11(1):97\u2013110. doi: 10.1007\/s40487-022-00213-4.<\/li>\n \t<li>Yang X, Desai K, Agrawal N, et al. Treatment, resource use and costs among pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas. <i>Pediatric Health Med Ther<\/i>. 2020;11:421\u2013428. doi: 10.2147\/PHMT.S265690.<\/li>\n \t<li>Armstrong AE, Belzberg AJ, Crawford JR, et al. Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-related plexiform neurofibromas. <i>BMC Cancer<\/i>. 2023;23(1):553. doi: 10.1186\/s12885-023-10996-y.<\/li>\n<li>EZMEKLY\u00ae (mirdametinib). Agencia Europa del Medicamento. Ficha t\u00e9cnica. Dubl\u00edn, Irlanda:SpringWorks Therapeutics Ireland Limited; 2025.<\/li>\n<li>KOSELUGO\u00ae (selumetinib). Agencia Europa del Medicamento. Ficha t\u00e9cnica. S\u00f6dert\u00e4lje, Suecia:AstraZeneca AB; 2026.<\/li>\n<\/ol><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Carga de la enfermedad NF1-NP NF1-NP: un complejo desaf\u00edo cl\u00ednico Carga de la enfermedad y necesidades insatisfechas Carga de la enfermedad NF1-NP Posible impacto en la vida cotidiana Los pacientes afectados por la NF1-NP y sus cuidadores suelen enfrentarse a una reducci\u00f3n de la calidad de vida que va m\u00e1s all\u00e1 de los s\u00edntomas f\u00edsicos&hellip;<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-21896","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This 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