{"id":21719,"date":"2025-06-04T07:47:52","date_gmt":"2025-06-04T07:47:52","guid":{"rendered":"https:\/\/ezmeklydev.wpenginepowered.com\/?page_id=21719"},"modified":"2026-03-11T15:12:06","modified_gmt":"2026-03-11T15:12:06","slug":"diagnose-und-behandlung","status":"publish","type":"page","link":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/","title":{"rendered":"Diagnose und Behandlung"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21719\" class=\"elementor elementor-21719 elementor-21698\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67e03c8e e-flex e-con-boxed e-con e-parent\" data-id=\"67e03c8e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-540f546e elementor-widget elementor-widget-spacer\" data-id=\"540f546e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-147bb69e the7-e-sticky-row-yes e-flex e-con-boxed e-con e-parent\" data-id=\"147bb69e\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-28951d77 e-con-full e-flex e-con e-child\" data-id=\"28951d77\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3e36c5f8 elementor-widget elementor-widget-text-editor\" data-id=\"3e36c5f8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#diagnosis-section\">Diagnose<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2d16bea1 e-con-full e-flex e-con e-child\" data-id=\"2d16bea1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-79088cb elementor-widget elementor-widget-text-editor\" data-id=\"79088cb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#management-section\">Behandlung<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-65b23ea4 e-con-full e-flex e-con e-parent\" data-id=\"65b23ea4\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1c746689 e-flex e-con-boxed e-con e-child\" data-id=\"1c746689\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a12e50f elementor-widget elementor-widget-heading\" data-id=\"5a12e50f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Diagnose und Behandlung von NF1-PN<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70edb3da e-con-full section e-flex e-con e-parent\" data-id=\"70edb3da\" data-element_type=\"container\" id=\"diagnosis-section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1dfb4ee2 e-flex e-con-boxed e-con e-child\" data-id=\"1dfb4ee2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7bcd2d69 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"7bcd2d69\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Diagnose<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11c7d85 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"11c7d85\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-11c7d85\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 6.10395C67.7217 -0.910952 56.3558 -0.910952 49.3409 6.10395C46.6339 8.81093 44.9986 12.1634 44.3831 15.6623C44.3659 15.7441 44.3401 15.8 44.3229 15.8775C42.4594 25.6295 44.6069 32.6315 32.3029 44.9398C19.9945 57.2439 18.4151 53.9645 8.28867 57.3472L8.3231 57.3859C6.57583 57.954 4.91894 58.8835 3.52887 60.2693C-1.17499 64.9775 -1.17499 72.6035 3.52887 77.3073C8.23703 82.0155 15.863 82.0155 20.5669 77.3073C21.957 75.9173 22.8866 74.2604 23.4546 72.5131L23.4934 72.5475C26.876 62.4168 23.5966 60.8417 35.9007 48.5333C48.2048 36.225 55.211 38.3725 64.963 36.5133C65.0448 36.5004 65.0965 36.4703 65.1739 36.4531C68.6771 35.8377 72.0339 34.198 74.7366 31.491C81.7515 24.4804 81.7515 13.1102 74.7366 6.09534\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2226_241)\"><path d=\"M47.0557 45.4884C46.3574 47.8483 45.0716 50.0728 43.1982 51.9336C37.2205 57.8714 27.53 57.8714 21.5522 51.9336C15.5744 45.9959 15.5744 36.3703 21.5522 30.4325C23.4596 28.5378 25.7417 27.2522 28.1686 26.5586\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M45.114 49.9209L56.6353 61.365C57.7508 62.4731 57.7508 64.2832 56.6353 65.3912L56.4564 65.5688C55.3409 66.6769 53.5186 66.6769 52.4031 65.5688L40.8818 54.1247\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M27.5469 43.6792L37.842 25.5191L47.7964 36.1936L57.3507 19.0654\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M41.4268 25.5193C41.4268 27.4816 39.8259 29.0718 37.8504 29.0718C35.8748 29.0718 34.2739 27.4816 34.2739 25.5193C34.2739 23.557 35.8748 21.9668 37.8504 21.9668C39.8259 21.9668 41.4268 23.557 41.4268 25.5193Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M31.1231 43.6795C31.1231 45.6418 29.5222 47.232 27.5467 47.232C25.5711 47.232 23.9702 45.6418 23.9702 43.6795C23.9702 41.7171 25.5711 40.127 27.5467 40.127C29.5222 40.127 31.1231 41.7171 31.1231 43.6795Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M51.3809 36.1931C51.3809 38.1555 49.78 39.7456 47.8045 39.7456C45.8289 39.7456 44.228 38.1555 44.228 36.1931C44.228 34.2308 45.8289 32.6406 47.8045 32.6406C49.78 32.6406 51.3809 34.2308 51.3809 36.1931Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M60.9356 19.0652C60.9356 21.0275 59.3347 22.6177 57.3592 22.6177C55.3836 22.6177 53.7827 21.0275 53.7827 19.0652C53.7827 17.1029 55.3836 15.5127 57.3592 15.5127C59.3347 15.5127 60.9356 17.1029 60.9356 19.0652Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.51\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2226_241\"><rect width=\"46\" height=\"53\" fill=\"white\" transform=\"translate(16 14.4551)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>NF1-PN wachsen <b>in der fr\u00fchen Kindheit schnell<\/b> und erfordern eine rechtzeitige <b>Beurteilung, Diagnose und Intervention<\/b> f\u00fcr eine effektive Behandlung.<sup>1<\/sup><br\/>\nEine <b>internationale Konsensempfehlung<\/b> beschreibt die diagnostischen Kriterien zur <b>Diagnosestellung von NF1<\/b>. Die diagnostischen Kriterien sind bei einer Person erf\u00fcllt, wenn zwei oder mehr* der folgenden Kriterien vorliegen:<sup>2,3<\/sup><\/p><ul>\n<li>Sechs oder mehr <b>Caf\u00e9-au-lait-Flecken<\/b><\/li>\n<li><b>Sommersprossen<\/b> in der Achsel- oder Leistengegend<\/li>\n<li>Zwei oder mehr Neurofibrome jeglicher Art oder ein <b>plexiformes Neurofibrom<\/b><\/li>\n<li>Optikusgliom<\/li>\n<li>Zwei oder mehr Lisch-Knoten in der Iris<\/li>\n<li>Eine charakteristische oss\u00e4re L\u00e4sion<\/li>\n<li>Eine heterozygote pathogene NF1-Variante<\/li><\/ul>\n<small>*Eines oder mehrere, wenn bei einem Elternteil der betroffenen Person bereits NF1 diagnostiziert wurde<\/small>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a9ac86a section e-con-full e-flex e-con e-parent\" data-id=\"a9ac86a\" data-element_type=\"container\" id=\"management-section\">\n\t\t<div class=\"elementor-element elementor-element-8b1ae14 e-flex e-con-boxed e-con e-child\" data-id=\"8b1ae14\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-606f696 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"606f696\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Behandlung von NF1-PN<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d97e4d8 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"d97e4d8\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-d97e4d8\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 5.64887C67.7217 -1.36603 56.3558 -1.36603 49.3409 5.64887C46.6339 8.35585 44.9986 11.7084 44.3831 15.2072C44.3659 15.289 44.3401 15.3449 44.3229 15.4224C42.4594 25.1744 44.6069 32.1764 32.3029 44.4847C19.9945 56.7888 18.4151 53.5094 8.28867 56.8921L8.3231 56.9308C6.57583 57.4989 4.91894 58.4285 3.52887 59.8142C-1.17499 64.5224 -1.17499 72.1484 3.52887 76.8523C8.23703 81.5604 15.863 81.5604 20.5669 76.8523C21.957 75.4622 22.8866 73.8053 23.4546 72.058L23.4934 72.0925C26.876 61.9617 23.5966 60.3866 35.9007 48.0783C48.2048 35.7699 55.211 37.9174 64.963 36.0583C65.0448 36.0453 65.0965 36.0152 65.1739 35.998C68.6771 35.3826 72.0339 33.7429 74.7366 31.0359C81.7515 24.0253 81.7515 12.6552 74.7366 5.64026\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2227_662)\"><path d=\"M51.9152 48.7373C49.0797 52.17 44.7927 54.3612 39.9968 54.3612C31.4634 54.3612 24.5512 47.4483 24.5512 38.914H28.6822L22.2652 27.7949L15.8481 38.914H19.8503C19.8503 50.0466 28.8722 59.0694 40.0036 59.0694\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M28.0781 29.0831C30.9136 25.6503 35.2006 23.4591 39.9965 23.4591C48.5299 23.4591 55.4421 30.372 55.4421 38.9064H51.3111L57.7281 50.0254L64.1451 38.9064H60.143C60.143 27.7738 51.1211 18.751 39.9897 18.751\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 32.7129H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 32.7198L34.9839 34.3615L38.2806 31.0645\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 38.9131H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 38.92L34.9839 40.5617L38.2806 37.2646\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.0249 45.1074H46.7936\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M33.3423 45.1143L34.9839 46.756L38.2806 43.459\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2227_662\"><rect width=\"50\" height=\"42\" fill=\"white\" transform=\"translate(15 17.9102)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Die europ\u00e4ische Leitlinie ERN GENTURIS zur Behandlung von NF1 empfiehlt einen <b>multidisziplin\u00e4ren Ansatz (MDT)<\/b>, an dem Spezialisten mit Erfahrung in der Behandlung von <b>PN im Zusammenhang mit NF1<\/b> beteiligt sind.<sup>3,4<\/sup><br\/>\n<b>Behandlungsm\u00f6glichkeiten<\/b> f\u00fcr Patienten mit PN im Zusammenhang mit NF1 umfassen aktive \u00dcberwachung, symptomatische Therapie, Operation und gezielte medikament\u00f6se Therapie.<sup>4,5<\/sup><br\/>\n<b>Leitlinien zur Behandlung von<\/b> PN im Zusammenhang mit NF1 <b>empfehlen eine medikament\u00f6se Therapie<\/b> als aktive Behandlungsoption f\u00fcr symptomatische PN und inoperable symptomatische PN.<sup>4,5<\/sup><\/p><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6299658 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"6299658\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">\u00dcberwachung von NF1-PN Patient:innen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6b1006 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"f6b1006\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-f6b1006\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Item link\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7366 6.21821C67.7217 -0.796694 56.3558 -0.796694 49.3409 6.21821C46.6339 8.92518 44.9986 12.2777 44.3831 15.7765C44.3659 15.8583 44.3401 15.9143 44.3229 15.9917C42.4594 25.7437 44.6069 32.7457 32.3029 45.0541C19.9945 57.3581 18.4151 54.0788 8.28867 57.4614L8.3231 57.5001C6.57583 58.0682 4.91894 58.9978 3.52887 60.3836C-1.17499 65.0917 -1.17499 72.7178 3.52887 77.4216C8.23703 82.1298 15.863 82.1298 20.5669 77.4216C21.957 76.0315 22.8866 74.3746 23.4546 72.6274L23.4934 72.6618C26.876 62.5311 23.5966 60.9559 35.9007 48.6476C48.2048 36.3392 55.211 38.4867 64.963 36.6276C65.0448 36.6147 65.0965 36.5845 65.1739 36.5673C68.6771 35.9519 72.0339 34.3122 74.7366 31.6053C81.7515 24.5947 81.7515 13.2245 74.7366 6.2096\" fill=\"#05C0DA\"><\/path><g clip-path=\"url(#clip0_2227_878)\"><path d=\"M15.6924 49.2838L23.7483 37.1743L28.317 43.366L39.6486 24.9942L45.2517 32.2584L55.3451 18.458\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M14.9795 60.501H64.0204\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.6377 54.7793H29.1717\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.6377 49.8867H29.1717\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 54.7793H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 49.8867H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.3779 45.002H43.9119\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M49.9932 54.7793H58.5271\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M49.9932 49.8867H53.5039\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M52.2027 29.4247C52.2027 35.1938 47.5243 39.867 41.7488 39.867C35.9733 39.867 31.2949 35.1938 31.2949 29.4247C31.2949 23.6556 35.9733 18.9824 41.7488 18.9824C47.5243 18.9824 52.2027 23.6556 52.2027 29.4247Z\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M50.6433 35.1074L61.7398 46.1916C62.5548 47.0057 62.5548 48.3364 61.7398 49.1505L61.6065 49.2835C60.7916 50.0976 59.4593 50.0976 58.6443 49.2835L47.5479 38.1994\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2227_878\"><rect width=\"51\" height=\"44\" fill=\"white\" transform=\"translate(14 17.4795)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Die <b>klinische Beurteilung<\/b> durch Beobachtung, Palpation und neurologische Untersuchung sollte regelm\u00e4\u00dfig von <b>\u00c4rzt:innen mit Erfahrung in NF1-PN<\/b> durchgef\u00fchrt werden.<sup>3,4<\/sup><br\/>\nDie Bildgebung durch <b>Ganzk\u00f6rper-MRT<\/b> sollte mindestens beim \u00dcbergang vom <b>Jugend- zum Erwachsenenalter<\/b> durchgef\u00fchrt werden.<sup>3,4<\/sup><br\/>\nDie klinische Beurteilung sollte <b>bei Diagnose oder Geburt begonnen<\/b> und bei jedem klinischen Besuchstermin wiederholt werden, mindestens:<sup>4<\/sup><\/p>\n<ul><li>J\u00e4hrlich bei Kindern bis zu 10 Jahren<\/li>\n<li>Einmal alle zwei Jahre bei Kindern \u00fcber 10 Jahren<\/li><li>Einmal alle drei Jahre bei Erwachsenen<\/li>\n<li>W\u00e4hrend des \u00dcbergangs vom Jugend- zum Erwachsenenalter kann eine h\u00e4ufigere klinische Beurteilung erforderlich sein.<\/li><\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc1e835 e-con-full e-flex e-con e-parent\" data-id=\"cc1e835\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-deb0c31 e-flex e-con-boxed e-con e-child\" data-id=\"deb0c31\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6f7135c e-con-full e-flex e-con e-child\" data-id=\"6f7135c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6d122f elementor-widget elementor-widget-the7-accordion\" data-id=\"d6d122f\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2251\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2251\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">Literatur<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2251\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2251\"><ol><li>Gross AM et al. Association of plexiform neurofibroma volume changes and development of clinical morbidities in neurofibromatosis 1. <i>Neuro Oncol <\/i>2018;20(12):1643\u20131651.<\/li><li>Legius E et al. Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: An international consensus recommendation. <i>Genet Med<\/i>. 2021;23(8):1506\u20131513.<\/li><li>Farschtschi S, Vaassen P, Kluwe L, Hartung T, Salamon J, Rosenbaum T. Age adapted diagnostic evaluation and treatment of patients with neurofibromatosis type 1 in Germany. <i>Dtsch Arztebl Int<\/i> 2025; 112(3)<\/li><li>Carton C et al. ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1.<i> eClinicalMedicine<\/i>. 2023;56:101818.<\/li><li>Fisher MJ, Blakeley JO, Weiss BD, et al. Management of neurofibromatosis type 1-associated plexiform neurofibromas.<i> Neuro Oncol<\/i>. 2022;24(11):1827-1844.<\/li><\/ol><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Diagnose Behandlung Diagnose und Behandlung von NF1-PN Diagnose NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.1 Eine internationale Konsensempfehlung beschreibt die diagnostischen Kriterien zur Diagnosestellung von NF1. Die diagnostischen Kriterien sind bei einer Person erf\u00fcllt, wenn zwei oder mehr* der folgenden Kriterien vorliegen:2,3 Sechs&hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-21719","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics<\/title>\n<meta name=\"description\" content=\"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics\" \/>\n<meta property=\"og:description\" content=\"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/\" \/>\n<meta property=\"og:site_name\" content=\"Springworks\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-11T15:12:06+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/\",\"url\":\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/\",\"name\":\"NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics\",\"isPartOf\":{\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#website\"},\"datePublished\":\"2025-06-04T07:47:52+00:00\",\"dateModified\":\"2026-03-11T15:12:06+00:00\",\"description\":\"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.nf1pn.eu\/de\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Diagnose und Behandlung\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#website\",\"url\":\"https:\/\/www.nf1pn.eu\/de\/\",\"name\":\"Springworks\",\"description\":\"NF1PN\",\"publisher\":{\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.nf1pn.eu\/de\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#organization\",\"name\":\"Springworks\",\"url\":\"https:\/\/www.nf1pn.eu\/de\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2024\/07\/SWTX_Logo_White.svg\",\"contentUrl\":\"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2024\/07\/SWTX_Logo_White.svg\",\"caption\":\"Springworks\"},\"image\":{\"@id\":\"https:\/\/www.nf1pn.eu\/de\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics","description":"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/","og_locale":"de_DE","og_type":"article","og_title":"NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics","og_description":"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.","og_url":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/","og_site_name":"Springworks","article_modified_time":"2026-03-11T15:12:06+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"2\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/","url":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/","name":"NF1-PN: Diagnose und Behandlung | SpringWorks Therapeutics","isPartOf":{"@id":"https:\/\/www.nf1pn.eu\/de\/#website"},"datePublished":"2025-06-04T07:47:52+00:00","dateModified":"2026-03-11T15:12:06+00:00","description":"NF1-PN wachsen in der fr\u00fchen Kindheit schnell und erfordern eine rechtzeitige Beurteilung, Diagnose und Intervention f\u00fcr eine effektive Behandlung.","breadcrumb":{"@id":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.nf1pn.eu\/de\/diagnose-und-behandlung\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.nf1pn.eu\/de\/"},{"@type":"ListItem","position":2,"name":"Diagnose und Behandlung"}]},{"@type":"WebSite","@id":"https:\/\/www.nf1pn.eu\/de\/#website","url":"https:\/\/www.nf1pn.eu\/de\/","name":"Springworks","description":"NF1PN","publisher":{"@id":"https:\/\/www.nf1pn.eu\/de\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.nf1pn.eu\/de\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.nf1pn.eu\/de\/#organization","name":"Springworks","url":"https:\/\/www.nf1pn.eu\/de\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.nf1pn.eu\/de\/#\/schema\/logo\/image\/","url":"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2024\/07\/SWTX_Logo_White.svg","contentUrl":"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2024\/07\/SWTX_Logo_White.svg","caption":"Springworks"},"image":{"@id":"https:\/\/www.nf1pn.eu\/de\/#\/schema\/logo\/image\/"}}]}},"featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/pages\/21719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/comments?post=21719"}],"version-history":[{"count":0,"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/pages\/21719\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.nf1pn.eu\/de\/wp-json\/wp\/v2\/media?parent=21719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}