{"id":21275,"date":"2024-08-02T11:02:59","date_gmt":"2024-08-02T11:02:59","guid":{"rendered":"https:\/\/site-euspringworks-live-1721707192-jq9cikhfcu2uwhr.local\/ressourcen-und-expertenvideos\/"},"modified":"2026-03-11T15:12:04","modified_gmt":"2026-03-11T15:12:04","slug":"krankheitslast-und-unmet-needs","status":"publish","type":"page","link":"https:\/\/www.nf1pn.eu\/de\/krankheitslast-und-unmet-needs\/","title":{"rendered":"Krankheitslast und Unmet Needs"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21275\" class=\"elementor elementor-21275 elementor-20178\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67e03c8e e-flex e-con-boxed e-con e-parent\" data-id=\"67e03c8e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-540f546e elementor-widget elementor-widget-spacer\" data-id=\"540f546e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-147bb69e the7-e-sticky-row-yes e-flex e-con-boxed e-con e-parent\" data-id=\"147bb69e\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-28951d77 e-con-full e-flex e-con e-child\" data-id=\"28951d77\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3e36c5f8 elementor-widget elementor-widget-text-editor\" data-id=\"3e36c5f8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#disease-burden\">Krankheitslast bei NF1-PN<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11e17bd e-con-full e-flex e-con e-child\" data-id=\"11e17bd\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d216c48 elementor-widget elementor-widget-text-editor\" data-id=\"d216c48\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"#unmet-needs\">NF1-PN: eine komplexe klinische Herausforderung<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-65b23ea4 e-con-full e-flex e-con e-parent\" data-id=\"65b23ea4\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1c746689 e-flex e-con-boxed e-con e-child\" data-id=\"1c746689\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a12e50f elementor-widget elementor-widget-heading\" data-id=\"5a12e50f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Krankheitslast und Unmet Needs<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70edb3da e-con-full section e-flex e-con e-parent\" data-id=\"70edb3da\" data-element_type=\"container\" id=\"disease-burden\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1dfb4ee2 e-flex e-con-boxed e-con e-child\" data-id=\"1dfb4ee2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7bcd2d69 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"7bcd2d69\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Krankheitslast bei NF1-PN<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-870df09 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"870df09\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">M\u00f6gliche Auswirkungen auf das t\u00e4gliche Leben<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8933621 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"8933621\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Von NF1-PN betroffene Patientinnen und Patienten sowie ihre Betreuer: innen sehen sich h\u00e4ufig einer Minderung der Lebensqualit\u00e4t ausgesetzt, die \u00fcber die k\u00f6rperlichen Symptome der Erkrankung hinausgeht.<\/p><p>Diese komplexe Erkrankung kann zu einer Vielzahl von k\u00f6rperlichen, psychologischen und kognitiven Einschr\u00e4nkungen f\u00fchren, welche die t\u00e4gliche Funktionsf\u00e4higkeit und das allgemeine Wohlbefinden beeintr\u00e4chtigen k\u00f6nnen.<sup>1\u20133<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11c7d85 no-link content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"11c7d85\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-11c7d85\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"K\u00f6rperliche Symptome\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><mask id=\"mask0_2098_3338\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"80\" height=\"81\"><path d=\"M80 0.0898438H0V80.0898H80V0.0898438Z\" fill=\"white\"><\/path><\/mask><g mask=\"url(#mask0_2098_3338)\"><mask id=\"mask1_2098_3338\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"80\" height=\"81\"><path d=\"M79.9527 0.0898438H0V80.0425H79.9527V0.0898438Z\" fill=\"white\"><\/path><\/mask><g mask=\"url(#mask1_2098_3338)\"><path opacity=\"0.3\" d=\"M74.6924 5.34596C67.6816 -1.6648 56.3225 -1.6648 49.3118 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Tumoren<\/li><\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Psychologische Auswirkungen\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"81\" height=\"81\" viewBox=\"0 0 81 81\" fill=\"none\"><path opacity=\"0.3\" d=\"M75.0259 5.34596C68.0151 -1.6648 56.656 -1.6648 49.6453 5.34596C46.9399 8.05133 45.3055 11.4019 44.6904 14.8986C44.6732 14.9804 44.6474 15.0363 44.6302 15.1137C42.7678 24.8599 44.9141 31.8578 32.6172 44.1589C20.3162 56.4556 18.7377 53.1782 8.61725 56.5589L8.65166 56.5976C6.90542 57.1653 5.24951 58.0943 3.86028 59.4793C-0.840796 64.1847 -0.840796 71.8062 3.86028 76.5073C8.56564 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14)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Psychologische Auswirkungen\">\t\t\t\t\t\t\t\t\t\t\t\tPsychologische Auswirkungen\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><ul><li>Depression<\/li>\n<li>Angst<\/li>\n<li>Isolation<\/li>\n<li>Stigma<\/li>\n<li>Verlegenheit<\/li>\n<li>Angst vor Krebs<\/li>\n<li>Eingeschr\u00e4nkte sexuelle Gesundheit<\/li><\/ul><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Kognitive Defizite\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"81\" height=\"81\" viewBox=\"0 0 81 81\" fill=\"none\"><mask id=\"mask0_2098_3394\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"81\" height=\"81\"><path d=\"M80.6665 0.0898438H0.666504V80.0898H80.6665V0.0898438Z\" fill=\"white\"><\/path><\/mask><g mask=\"url(#mask0_2098_3394)\"><mask id=\"mask1_2098_3394\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"81\" height=\"81\"><path d=\"M80.6192 0.0898438H0.666504V80.0425H80.6192V0.0898438Z\" fill=\"white\"><\/path><\/mask><g mask=\"url(#mask1_2098_3394)\"><path opacity=\"0.3\" d=\"M75.3589 5.34596C68.3482 -1.6648 56.989 -1.6648 49.9783 5.34596C47.2729 8.05133 45.6385 11.4019 45.0234 14.8986C45.0062 14.9804 44.9804 15.0363 44.9632 15.1137C43.1008 24.8599 45.2471 31.8578 32.9503 44.1589C20.6492 56.4556 19.0707 53.1782 8.95026 56.5589L8.98467 56.5976C7.23843 57.1653 5.58252 58.0943 4.19329 59.4793C-0.507788 64.1847 -0.507788 71.8062 4.19329 76.5073C8.89865 81.2126 16.5202 81.2126 21.2212 76.5073C22.6105 75.118 23.5395 73.4621 24.1072 71.7159L24.146 71.7503C27.5266 61.6255 24.2492 60.0513 36.546 47.7503C48.8428 35.4492 55.8449 37.5954 65.5912 35.7374C65.6729 35.7244 65.7245 35.6943 65.8019 35.6771C69.303 35.0621 72.6578 33.4234 75.3589 30.718C82.3697 23.7115 82.3697 12.3481 75.3589 5.33735\" fill=\"#05C0DA\"><\/path><\/g><path d=\"M64.1268 31.8195C60.4136 25.8891 51.9744 20.8369 41.0542 20.8369C27.7625 20.8369 16.9941 27.6978 16.9941 36.1587C16.9941 39.5848 19.028 43.9152 22.8172 45.2978C22.8172 45.2978 20.3192 54.4022 33.3577 54.8283C37.0793 54.95 41.5099 53.7848 46.202 51.4196C60.2617 44.3152 75.258 49.6283 64.1099 31.8195H64.1268Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M39.9941 47.6612C39.9941 47.6612 35.6418 51.1936 30.761 49.2565C28.4155 48.3286 27.92 46.4892 28.0026 44.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M30.9941 30.3336C32.8551 27.6541 36.3591 25.8369 40.3829 25.8369C44.633 25.8369 48.3047 27.8581 50.0734 30.7972C52.2781 31.27 53.8625 32.0396 54.9941 32.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M39.9941 53.8369C41.5077 55.9182 43.0934 60.1927 42.9893 64.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M47.9941 64.8369V57.1406C49.9908 57.5784 52.215 57.5434 54.4307 56.913C59.6625 55.4245 63.1251 50.171 62.9903 45.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M46.9941 17.9262L50.4684 15.8369L54.2322 18.2372L58.8149 15.8369L59.9895 20.8927L64.9941 21.8975V25.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M25.0068 56.8369L23.9941 59.0507L29.3713 58.6044L32.9381 63.8369L35.9941 59.2344\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M22.9941 21.6016L20.3704 19.8369L19.1988 25.3392L12.9941 27.131L14.57 31.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M53.9941 60.8369L56.4536 61.8369L57.9941 60.8369\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/g><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Kognitive Defizite\">\t\t\t\t\t\t\t\t\t\t\t\tKognitive Defizite\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><ul><li>Konzentrationsschwierigkeiten<\/li>\n<li>Ged\u00e4chtnisst\u00f6rungen<\/li>\n<li>Beeintr\u00e4chtigte visuelle und motorische Funktionsf\u00e4higkeit<\/li>\n<li>Lernbehinderungen<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3631621 e-flex e-con-boxed e-con e-child\" data-id=\"3631621\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b7b5fb6 e-flex e-con-boxed e-con e-child\" data-id=\"b7b5fb6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-738b89e e-con-full e-flex e-con e-child\" data-id=\"738b89e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6ffecc elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"a6ffecc\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Schmerzen und Entstellung: Hauptbedenken in jedem Alter<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ef9329 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"9ef9329\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"the7-heading-title elementor-size-default\">In allen Altersgruppen sind zwei der am h\u00e4ufigsten gemeldeten Bedenken von Patientinnen und Patienten mit NF1-PN die m\u00f6glichen Schmerzen und die m\u00f6glichen Ver\u00e4nderungen des k\u00f6rperlichen Erscheinungsbildes.<sup>3<\/sup><br\/>\u2028Bei Kindern und Jugendlichn k\u00f6nnen Schmerzen nachweislich Auswirkungen auf ihre Lebensqualit\u00e4t haben, selbst wenn Schmerzmittel verwendet werden.<sup>4<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a9ac86a section e-flex e-con-boxed e-con e-parent\" data-id=\"a9ac86a\" data-element_type=\"container\" id=\"unmet-needs\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b284e06 e-con-full e-flex e-con e-child\" data-id=\"b284e06\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-3662c0c e-con-full e-flex e-con e-child\" data-id=\"3662c0c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-f5452cf e-con-full e-flex e-con e-child\" data-id=\"f5452cf\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-694feb5 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"694feb5\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">NF1-PN: eine komplexe klinische Herausforderung<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47b1afe no-link icon-box-grid-title-evidence content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"47b1afe\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-47b1afe\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Tumorwachstum und -verteilung\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"81\" viewBox=\"0 0 80 81\" fill=\"none\"><g clip-path=\"url(#clip0_2104_4056)\"><path opacity=\"0.3\" d=\"M74.7366 5.34907C67.7217 -1.66583 56.3558 -1.66583 49.3409 5.34907C46.6339 8.05604 44.9986 11.4086 44.3831 14.9074C44.3659 14.9892 44.3401 15.0451 44.3229 15.1226C42.4594 24.8746 44.6069 31.8766 32.3029 44.1849C19.9945 56.489 18.4151 53.2096 8.28867 56.5923L8.3231 56.631C6.57583 57.1991 4.91894 58.1287 3.52887 59.5144C-1.17499 64.2226 -1.17499 71.8486 3.52887 76.5525C8.23703 81.2606 15.863 81.2606 20.5669 76.5525C21.957 75.1624 22.8866 73.5055 23.4546 71.7582L23.4934 71.7927C26.876 61.6619 23.5966 60.0868 35.9007 47.7785C48.2048 35.4701 55.211 37.6176 64.963 35.7584C65.0448 35.7455 65.0965 35.7154 65.1739 35.6982C68.6771 35.0828 72.0339 33.4431 74.7366 30.7361C81.7515 23.7255 81.7515 12.3554 74.7366 5.34046\" fill=\"#05C0DA\"><\/path><path d=\"M49.4191 39.8429C49.4191 47.3699 43.1272 53.4767 35.3549 53.4767C27.5825 53.4767 21.2949 47.3699 21.2949 39.8429C21.2949 32.3158 27.5954 26.209 35.3549 26.209C43.1143 26.209 49.4191 32.3158 49.4191 39.8429Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M11.3662 67.2098L26.3686 50.7441\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M32.1992 75.0419C31.4848 75.0419 30.8565 74.4609 30.8005 73.7465L29.4191 55.6196C29.3416 55.611 29.2641 55.6024 29.1781 55.5895C27.3662 55.3313 25.8858 53.9197 25.7395 52.3101L24.7109 38.9302C24.7066 38.8183 24.7109 38.7408 24.7109 38.6978C24.7109 36.0295 26.8756 33.8132 29.5353 33.7529H40.7247C43.4015 33.8175 45.5662 36.0338 45.5662 38.6935C45.5662 38.7408 45.5662 38.8183 45.5662 38.913L44.5377 52.3015C44.3914 53.9197 42.9152 55.3313 41.0991 55.5895C41.0173 55.6024 40.9398 55.611 40.8624 55.6196L39.4809 73.7465C39.4293 74.4609 38.8009 75.0419 38.0822 75.0419H32.1949H32.1992Z\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M35.1429 31.3258C32.6253 31.3258 30.5811 29.2773 30.5811 26.764C30.5811 24.2507 32.6296 22.2021 35.1429 22.2021C37.6562 22.2021 39.7047 24.2507 39.7047 26.764C39.7047 29.2773 37.6562 31.3258 35.1429 31.3258Z\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M35.1387 54.3457V74.4694\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M29.3801 55.0519L28.2568 40.3809\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><path d=\"M40.9102 55.0519L42.0291 40.3809\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linejoin=\"round\"><\/path><\/g><defs><clipPath id=\"clip0_2104_4056\"><rect width=\"80\" height=\"80\" fill=\"white\" transform=\"translate(0 0.0898438)\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Tumorwachstum und -verteilung\">\t\t\t\t\t\t\t\t\t\t\t\tTumorwachstum und -verteilung\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\">Plexiforme Neurofibrome (PN) sind komplexe Tumoren, die sich \u00fcberall im K\u00f6rper au\u00dferhalb des zentralen Nervensystems (ZNS) entwickeln k\u00f6nnen. Die h\u00e4ufigsten Lokalisationen sind der Kopf- und Halsbereich, gefolgt von den Extremit\u00e4ten und dem Rumpf.<sup>5,6<\/sup><br\/>\nDas Wachstumsverhalten von PN ist unvorhersehbar, wobei Phasen der schnellen Expansion mit Phasen der relativen Inaktivit\u00e4t abwechseln.<sup>7<\/sup>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5ae02cf e-con-full e-flex e-con e-child\" data-id=\"5ae02cf\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5aaf8d8 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"5aaf8d8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Eine Operation zur Behandlung von NF1-PN ist nicht immer m\u00f6glich und die Ergebnisse k\u00f6nnen variabel sein.<sup>8<\/sup><\/strong>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d6318b no-link icon-box-grid-title-evidence content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"9d6318b\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-9d6318b\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Chirurgische Behandlungen: Einschr\u00e4nkungen und Ergebnisse\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"84\" height=\"86\" viewBox=\"0 0 84 86\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7356 5.35102C67.7207 -1.66388 56.3548 -1.66388 49.3399 5.35102C46.633 8.058 44.9976 11.4105 44.3822 14.9094C44.3649 14.9911 44.3391 15.0471 44.3219 15.1245C42.4584 24.8765 44.6059 31.8785 32.3019 44.1869C19.9935 56.4909 18.4141 53.2116 8.2877 56.5942L8.32213 56.633C6.57486 57.201 4.91796 58.1306 3.52789 59.5164C-1.17596 64.2245 -1.17596 71.8506 3.52789 76.5544C8.23605 81.2626 15.8621 81.2626 20.5659 76.5544C21.956 75.1643 22.8856 73.5075 23.4537 71.7602L23.4924 71.7946C26.875 61.6639 23.5957 60.0888 35.8997 47.7804C48.2038 35.4721 55.2101 37.6196 64.9621 35.7604C65.0438 35.7475 65.0955 35.7174 65.173 35.7001C68.6761 35.0847 72.0329 33.445 74.7356 30.7381C81.7505 23.7275 81.7505 12.3573 74.7356 5.34241\" fill=\"#05C0DA\"><\/path><path d=\"M63.6044 24.1366L55.957 16.4893L43.2429 29.2034L50.8902 36.8508L63.6044 24.1366Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M49.1521 35.1155L44.98 30.9434L40.8079 35.1155L44.98 39.2876L49.1521 35.1155Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M42.8931 37.1982L11.1797 68.9116\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.9812 25.4659L44.3302 22.8149C42.5097 20.9945 42.5097 18.0422 44.3302 16.2218C46.1506 14.4013 49.1029 14.4013 50.9276 16.2218L53.5786 18.8728\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M61.222 26.5166L63.873 29.1676C65.6934 30.9881 65.6934 33.9403 63.873 35.7651C62.0526 37.5855 59.1003 37.5855 57.2755 35.7651L54.6245 33.1141\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M67.0876 17.1731L62.9155 13.001L57.6935 18.223L61.8657 22.3951L67.0876 17.1731Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><path d=\"M71.4001 21.4851L58.6055 8.69043\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-miterlimit=\"10\"><\/path><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Chirurgische Behandlungen: Einschr\u00e4nkungen und Ergebnisse\">\t\t\t\t\t\t\t\t\t\t\t\tChirurgische Behandlungen: Einschr\u00e4nkungen und Ergebnisse\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Historisch gesehen war <b>die prim\u00e4re Behandlungsoption f\u00fcr PN eine chirurgische Resektion<\/b>; inoperable Tumoren, unvollst\u00e4ndige Resektionen und erneutes Wachstum der Tumoren k\u00f6nnen jedoch den Nutzen chirurgischer Interventionen einschr\u00e4nken.<sup>5<\/sup><br\/>\n<b>Chirurgische Eingriffe bei NF1-PN werden oft<\/b> durch die infiltrative Natur der Tumoren, ihre anatomische Lage und ihre N\u00e4he zu Nerven und Blutgef\u00e4\u00dfen <b>eingeschr\u00e4nkt<\/b>.<sup>2<\/sup><br\/>\n<b>Auch wenn eine Operation m\u00f6glich ist:<\/b><\/p>\n<ul><li>Eine vollst\u00e4ndige Entfernung eines plexiformen Neurofibroms (PN) ist in vielen F\u00e4llen nicht m\u00f6glich.<sup>9<\/sup><\/li>\n<li>Etwa 50% der Patienten haben Tumore, die nicht vollst\u00e4ndig reseziert werden k\u00f6nnen.<sup>10<\/sup><\/li>\n<li>Auch nach vollst\u00e4ndigen Resektionen k\u00f6nnen 20% der Tumoren erneut wachsen.<sup>10<\/sup><\/li><\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Der Bedarf an weiteren Therapieoptionen\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"84\" height=\"86\" viewBox=\"0 0 84 86\" fill=\"none\"><path opacity=\"0.3\" d=\"M74.7356 5.35102C67.7207 -1.66388 56.3548 -1.66388 49.3399 5.35102C46.633 8.058 44.9976 11.4105 44.3822 14.9094C44.3649 14.9911 44.3391 15.0471 44.3219 15.1245C42.4584 24.8765 44.6059 31.8785 32.3019 44.1869C19.9935 56.4909 18.4141 53.2116 8.2877 56.5942L8.32213 56.633C6.57486 57.201 4.91796 58.1306 3.52789 59.5164C-1.17596 64.2245 -1.17596 71.8506 3.52789 76.5544C8.23605 81.2626 15.8621 81.2626 20.5659 76.5544C21.956 75.1643 22.8856 73.5075 23.4537 71.7602L23.4924 71.7946C26.875 61.6639 23.5957 60.0888 35.8997 47.7804C48.2038 35.4721 55.2101 37.6196 64.9621 35.7604C65.0438 35.7475 65.0955 35.7174 65.173 35.7001C68.6761 35.0847 72.0329 33.445 74.7356 30.7381C81.7505 23.7275 81.7505 12.3573 74.7356 5.34241\" fill=\"#05C0DA\"><\/path><path d=\"M45.1434 59.79C45.1587 59.9457 45.1682 60.1051 45.1682 60.2645C45.1682 62.802 43.0936 64.8593 40.5347 64.8593H40.3166C37.7577 64.8593 35.6812 62.802 35.6812 60.2645C35.6812 60.1051 35.6888 59.9457 35.7041 59.79\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M55.2505 51.0176L58.1998 53.7486\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M35.5549 19.8793L34.5635 16\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M27.0209 24.3986L24.3262 21.4189\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M21.5665 32.4202L17.7617 31.0859\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M20.9407 42.3428L17 43.2101\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M25.6011 51.0176L22.6499 53.7486\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M59.9111 42.3428L63.8518 43.2101\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M59.2832 32.4202L63.0899 31.0859\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M53.8286 24.3986L56.5234 21.4189\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M45.2949 19.8793L46.2863 16\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M42.8199 60.2648C45.9606 60.2648 48.6017 57.7937 48.6323 54.6793C48.6323 54.6527 48.6323 54.4591 48.6323 54.4591C48.6323 51.9197 49.639 49.4639 51.4706 47.5166C53.9816 44.8501 55.4055 41.3466 55.1319 37.5432C54.6285 30.557 48.2974 24.3965 40.4256 24.3965C32.5539 24.3965 26.2209 30.5589 25.7175 37.5451C25.4438 41.3485 26.8677 44.852 29.3787 47.5185C31.2122 49.4639 32.217 51.9216 32.217 54.461C32.217 54.461 32.217 54.6546 32.217 54.6812C32.2476 57.7956 34.8888 60.2667 38.0295 60.2667H42.8199V60.2648Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><path d=\"M41.8114 55.7913L41.8229 55.7173C42.1846 53.3885 42.5463 52.4681 42.908 50.1394L43.5377 46.0836C43.7597 44.6563 43.8401 41.9784 45.9607 42.1701C47.4382 42.3049 48.1023 44.1401 47.0573 45.1764C45.6142 46.6074 43.3023 46.4005 43.3023 46.4005H37.5511C37.5511 46.4005 35.2391 46.6074 33.7961 45.1764C32.7511 44.1401 33.4152 42.303 34.8927 42.1701C37.0133 41.9765 37.0937 44.6563 37.3157 46.0836L37.9453 50.1394C38.3071 52.4681 38.6688 53.3885 39.0305 55.7173L39.042 55.7913\" stroke=\"#005EA7\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Der Bedarf an weiteren Therapieoptionen\">\t\t\t\t\t\t\t\t\t\t\t\tDer Bedarf an weiteren Therapieoptionen\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\">Da eine chirurgischen Behandlung nicht immer m\u00f6glich ist oder an ihre Grenzen st\u00f6\u00dft, besteht weiterhin ein Bedarf an nicht-chirurgischen Behandlungsoptionen f\u00fcr Patienten mit NF1-PN.\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fb04d84 e-con-full e-flex e-con e-child\" data-id=\"fb04d84\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f9a4ec content-align-left the7-hover-visibility-disabled transform-overlay-yes exceeding-frame-yes elementor-widget elementor-widget-the7-image-widget\" data-id=\"6f9a4ec\" data-element_type=\"widget\" data-settings=\"{&quot;hover_visibility&quot;:&quot;disabled&quot;}\" data-widget_type=\"the7-image-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"the7-image-container\"><div class=\"the7-image-wrapper the7-elementor-widget the7-transform-container\"><div class=\"post-thumbnail-rollover layzr-bg img-css-resize-wrapper\"><img decoding=\"async\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039;%20viewBox%3D&#039;0%200%201%201&#039;%2F%3E\" class=\"attachment-full size-full preload-me aspect the7-svg-image lazy lazy-load\" alt=\"\" data-src=\"https:\/\/www.nf1pn.eu\/wp-content\/uploads\/2025\/07\/Asset-1-1.svg\" loading=\"eager\" \/><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3017dfb elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"3017dfb\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">H\u00e4ufige Lokalisation von PN<sup>5,6<\/sup><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc1e835 e-con-full e-flex e-con e-parent\" data-id=\"cc1e835\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-deb0c31 e-flex e-con-boxed e-con e-child\" data-id=\"deb0c31\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6f7135c e-con-full e-flex e-con e-child\" data-id=\"6f7135c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6d122f elementor-widget elementor-widget-the7-accordion\" data-id=\"d6d122f\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2251\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2251\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">Literatur<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2251\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2251\"><ol><li>Copley-Merriman C, Yang X, Juniper M, et al. Natural History and Disease Burden of Neurofibromatosis Type 1 with Plexiform Neurofibromas: A Systematic Literature Review. <i>Adolesc Health Med Ther<\/i>. 2021;12:55-66.<\/li><li>Fisher MJ, Blakeley JO, Weiss BD, et al. Management of neurofibromatosis type 1-associated plexiform neurofibromas. <i>Neuro Oncol<\/i>. 2022;24(11):1827-1844.<\/li><li>Lai J-S, Jensen SE, Patel ZS, Listernick R, Charrow J. Using a qualitative approach to conceptualize concerns of patients with neurofibromatosis type 1 associated plexiform neurofibromas (pNF) across the lifespan. <i>Am J Med Genet A<\/i>. 2017;173(1):79-87.<\/li><li>Wolters PL, Burns KM, Martin S, et al. Pain interference in youth with neurofibromatosis type 1 and plexiform neurofibromas and relation to disease severity, social-emotional functioning, and quality of life. <i>Am J Med Genet A<\/i>. 2015;167A(9):2103-2113.<\/li><li>Prada CE, Rangwala FA, Martin LJ, et al. Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1. <i>J Pediatr<\/i>. 2012;160(3):461-467.<\/li><li>Darrigo LG Jr, Ferraz VEF, Cormedi MCV, et al. Epidemiological profile and clinical characteristics of 491 Brazilian patients with neurofibromatosis type 1. <i>Brain Behav<\/i>. 2022;12(6):e2599.<\/li><li>Nguyen R, Dombi E, Widemann BC, et al. Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. <i>Orphanet J Rare Dis<\/i>. 2012:7:75.<\/li><li>Ejerskov C, Farholt S, Nielsen FSK, et al. Clinical characteristics and management of children and adults with neurofibromatosis type 1 and plexiform neurofibromas in Denmark: a nationwide study. <i>Oncol Ther<\/i>. 2023;11(1):97-110.<\/li><li>Yang X, Desai K, Agrawal N, et al. Treatment, resource use and costs among pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas. <i>Pediatric Health Med Ther<\/i>. 2020;11:421-428.<\/li><li>Armstrong AE, Belzberg AJ, Crawford JR, et al. Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-related plexiform neurofibromas. <i>BMC Cancer<\/i>. 2023;23(1):553.<\/li><\/ol><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Krankheitslast bei NF1-PN NF1-PN: eine komplexe klinische Herausforderung Krankheitslast und Unmet Needs Krankheitslast bei NF1-PN M\u00f6gliche Auswirkungen auf das t\u00e4gliche Leben Von NF1-PN betroffene Patientinnen und Patienten sowie ihre Betreuer: innen sehen sich h\u00e4ufig einer Minderung der Lebensqualit\u00e4t ausgesetzt, die \u00fcber die k\u00f6rperlichen Symptome der Erkrankung hinausgeht. Diese komplexe Erkrankung kann zu einer Vielzahl von&hellip;<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-21275","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NF1-PN: Krankheitslast und Unmet Needs | SpringWorks Therapeutics<\/title>\n<meta name=\"description\" content=\"Von NF1-PN betroffene Patient:innen sehen sich h\u00e4ufig einer Minderung der Lebensqualit\u00e4t ausgesetzt, die \u00fcber die k\u00f6rperlichen Symptome der Erkrankung hinausgeht.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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